Protein kinases play a central role in tumor progression, regulating fundamental processes such as angiogenesis, proliferation and metastasis.Such enzymes are an increasingly important class of drug target with small molecule kinase inhibitors being a major focus in drug development.However, balancing drug specificity and efficacy is problematic wi
BackgroundThe stabilization or regulated reorganization of the actin cytoskeleton is essential for cellular structure and function.Recently, we could show that the activation of the SK3-channel that represents the predominant SK-channel in neural stem cells, leads to a rapid local outgrowth of long filopodial processes.This observation indicates th
Prebiotic oligosaccharides are used to modulate enteric pathogens and reduce pathogen shedding.The interactions with prebiotics that alter Listeria monocytogenes infection are not yet clearly delineated.L.monocytogenes cellular invasion requires Strontium Citrate a concerted manipulation of host epithelial cell membrane receptors to initiate intern
The development of blockchain and distributed ledger technology (DLT) technologies stimulates diametrically opposite points of view about the prospects of traditional institutions in the digital economy: from their complete disappearance to a cardinal transformation.This matter also applies to the field of accounting and auditing.The purpose of the
This article gives visibility to Amazonian indigenous peoples in the global process of plant circulation and associated knowledge.The first part highlights the indigenous role in cultivating and collecting native plants, and in the processing of natural products over the second half of the eighteenth century.The second part shows that these activit